A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase

Chembiochem. 2015 Mar 23;16(5):766-71. doi: 10.1002/cbic.201402650. Epub 2015 Feb 25.

Abstract

Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.

Keywords: Photorhabdus; biosynthesis; entomopathogenic bacteria; juvenile hormone epoxide hydrolase inhibitor; natural products.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biological Products / chemistry
  • Biological Products / metabolism
  • Biological Products / pharmacology*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Enzyme Inhibitors / pharmacology*
  • Epoxide Hydrolases / antagonists & inhibitors*
  • Epoxide Hydrolases / metabolism
  • Insecta
  • Photorhabdus / chemistry*
  • Structure-Activity Relationship
  • Urea / analogs & derivatives
  • Urea / metabolism
  • Urea / pharmacology*

Substances

  • Biological Products
  • Enzyme Inhibitors
  • Urea
  • Epoxide Hydrolases
  • juvenile hormone epoxide hydrolase